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Stem cells then and now - a brief history

Posted by James Andrews on Wed, Dec 19, 2012 @ 11:13 AM

Stem cell historyStem cells are how we all begin:
undifferentiated cells that go on to develop into any of the more than 200 types of cell the adult human body holds.

Few quarrel with predictions of the awesome potential that stem cell research holds. One day, scientists say, stem cells may be used to replace or repair damaged cells, and have the potential to drastically change the treatment of conditions like cancer, Alzheimer’s and Parkinson’s disease and even paralysis.

But the divisions over how to conduct that research have been deep and bitter, and have most recently played out in the courts. Most research has been conducted on embryonic stem cell lines — cultures of cells derived from four- or five-day-old embryos, or fertilized cells. Opponents of embryonic stem cell research, which often uses embryos discarded by fertility clinics, want it to be severely restricted or banned outright as inhumane.

The most important legislation relating to stem cell research is known as the Dickey-Wicker amendment, which first became law in 1996, and has been renewed by Congress every year since. It specifically bans the use of tax dollars to create human embryos — a practice that is routine in private fertility clinics — or for research in which embryos are destroyed, discarded or knowingly subjected to risk of injury.

For a time, the ban stood in the way of taxpayer-financed embryonic stem cell research, because embryos are destroyed when stem cells are extracted from them. But in August 2001, in a careful compromise, President George W. Bush opened the door a tiny crack, by ordering that tax dollars could be used for studies on a small number of lines, or colonies, of stem cells already extracted from embryos — so long as federal researchers did not do the extraction themselves.

Congress continued to be inundated with calls from people suffering from diseases for which stem cells research might be the only hope, and from equally vehement opponents. In 2006, the Republican-controlled Congress passed a bill to expand research. In response, Mr. Bush issued the first veto of his presidency. In 2007, Congress, now in Democratic hands, passed a similar bill by a larger margin, but still not by enough to override Mr. Bush’s veto.

In March 2009, President Obama issued an executive order rescinding the limits set by Mr. Bush and making clear that the government supported stem-cell research.

In August 2010, Chief Judge Royce C. Lamberth of Federal District Court blocked Mr. Obama’s executive order, saying it violated a ban on federal money being used to destroy embryos.

In May 2011, a federal appeals panel voted 2 to 1 to overturn Judge Lambert’s ruling. The appeals court said that because the law is written in the present tense, “it does not extend to past actions,” meaning that research on existing lines of stem cells could continue. The ruling, however is just the latest in what is bound to be a lengthy legal battle.

Using Stem Cells for Organ Regeneration

Tissue engineers have succeeded in making artificial organs that use a patient’s cells to become a living part of the body, with hope for eventual organ regeneration.

So far, only a few organs have been made and transplanted, and they are relatively simple, hollow ones — like bladders and a windpipe, which was implanted in June 2011. But scientists around the world are using similar techniques with the goal of building more complex organs. At Wake Forest University in North Carolina, for example, where bladders were developed, researchers are working on kidneys, livers and more. Labs in China and the Netherlands are among many working on blood vessels.

Researchers are making use of advances in knowledge of stem cells, basic cells that can be transformed into types that are specific to tissues like liver or lung. They are learning more about what they call scaffolds, compounds that act like mortar to hold cells in their proper place and that also play a major role in how cells are recruited for tissue repair.

The work of these new body builders is far different from the efforts that produced artificial hearts decades ago. Those devices, which are still used temporarily by some patients awaiting transplants, are sophisticated machines, but in the end they are only that: machines.

Today, tissue engineers are aiming to produce something that is more human. They want to make organs with the cells, blood vessels and nerves to become a living, functioning part of the body. Some want to go even further — to harness the body’s repair mechanisms so that it can remake a damaged organ on its own.

Tissue engineers caution that the work they are doing is experimental and costly, and that the creation of complex organs is still a long way off. But they are increasingly optimistic about the possibilities.

Want to know more about stem cells and how you can preserve them?

Speak to a stem cell specialist  Your free stem cell info guide

Tags: Dental Stem Cells, Research, Healthcare, Regenerative Medicine, Adult Stem Cells

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